What is SERMORELIN ACETATE?
SERMORELIN ACETATE is a synthetic peptide that mimics the action of growth hormone-releasing hormone (GHRH), a naturally occurring hormone in the body. It is primarily used to stimulate the pituitary gland to produce and release more of your own natural growth hormone (GH). It consists of the first 29 amino acids of naturally occurring GHRH and works by binding to the GHRH receptor (GHRHr) in the pituitary, which regulates GH secretion. This process involves both the stimulation of GH release by GHRH and the inhibition of GH release by somatostatin, creating a rhythmic, circadian pattern of GH secretion. By influencing the amplitude and frequency of GH pulses, SERMORELIN ACETATE increases the production of insulin-like growth factor 1 (IGF-1) in the liver and peripheral tissues. SERMORELIN ACETATE has been shown to simulate a naturally occurring GHRH-mediated GH release response, with doses of 3 mcg/kg producing effective results. In addition to boosting GH production, SERMORELIN ACETATE also impacts sleep patterns by increasing the amount of slow-wave sleep (SWS), which is associated with enhanced sleep-related GH secretion and reduced cortisol levels. However, to exert its full benefits, SERMORELIN ACETATE requires functioning pituitary and healthy peripheral tissues, as it relies on endogenous receptors to regulate hormone-secreting glands and tissues. Specifically, functioning growth hormone releasing hormone receptors (GHRHr) on somatotrophs in the anterior pituitary are necessary for SERMORELIN ACETATE to work effectively.
 

Potential Side Effects:

• Injection Site Reactions: Pain, swelling, itching, or redness (about 16% of patients)

• Metabolic Effects: Reduced insulin sensitivity, elevated blood sugar (harmful for diabetics)

• Hormonal Effects: Decreased thyroid hormone (T3) levels, affecting sodium, potassium, and phosphorus levels

• Upper respiratory conditions, nerve sensitivity, insomnia, depression

• Chest pain, gynecomastia (breast enlargement), headache, flushing

• Dizziness, hyperactivity, somnolence (drowsiness), urticaria (hives), sore bones

• Antibody Formation: Rare, but antibodies may form with chronic use, though they don't appear to affect GH release

• Allergic Reactions: Severe redness, sensitivity, swelling, and hives at injection sites (reported in one patient with antibodies)

 

Contraindications:

• Hypothyroidism: Untreated hypothyroidism may affect the response to SERMORELIN ACETATE; thyroid hormone levels should be monitored.

• Intracranial Lesions: Not recommended for GH deficiency caused by intracranial lesions.

• Obesity & Metabolic Disorders: Suboptimal GH response in patients with obesity, hyperglycemia, or high plasma fatty acids.

• Pregnancy & Breastfeeding: Contraindicated in pregnant or breastfeeding women (not mentioned specifically in the provided details, but general caution advised for hormonal treatments).

*This list may not cover all possible side effects—consult a healthcare provider for concerns.

 

How should I use this medication?
For comprehensive guidance on how to use your medication, please refer to the detailed instructions provided on the white prescription label affixed to the medication box or prescription vial.
It is to be administered subcutaneously. See detailed instructions here.
 

Where should I keep my medication?
Store refrigerated (36°F to 46°F), away from heat, moisture, and light. Keep out of reach of children. Dispose of unused medicine properly—do not flush or pour down the drain. If crystals form due to low temperatures, warm and shake the vial to dissolve them.
 

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.