What is NAD+?
Nicotinamide Adenine Dinucleotide (NAD+) is a crucial coenzyme and signaling molecule found in all cells, vital for cell function and viability. It plays a key role in cellular respiration, including glycolysis, the Krebs cycle, and the electron transport chain, where it partners with NADH. NADP+ and NADPH are also essential for anabolic processes like cholesterol and nucleic acid production, fatty acid elongation, and antioxidant regeneration. NAD+ is a precursor for cyclic ADP ribose, important in calcium signaling. The body produces NAD+ from tryptophan, vitamin B3 (niacin), and intermediates like nicotinamide mononucleotide.

 

NAD+ is recycled within cells, but its levels decrease with age, dropping to about half by age 50, contributing to mitochondrial dysfunction and age-related diseases. Research suggests that increasing levels of CD38, an enzyme that degrades NAD+, and oxidative stress contribute to this decline. NAD+ depletion is linked to diseases like diabetes, heart disease, Alzheimer’s, and vision loss, and maintaining adequate levels is important for health. Historically, NAD+ deficiency was linked to pellagra, treatable with vitamin B3. NAD+ IV infusion has been used in addiction treatment, though clinical trials on its effectiveness are limited. Ongoing research explores NAD+ replacement therapy's potential to improve mitochondrial function, genomic stability, neuroprotection, and lifespan.
 

Potential Side Effects:

• Headache

• Shortness of breath

• Constipation

• Increased plasma bilirubin

• Decreased levels of liver enzymes

• Injection Site Reactions: Pain, swelling, itching, or redness

• Allergic Reactions: Severe redness, sensitivity, swelling, and hives at injection sites

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The safety of NAD+ injection has not been studied in pregnant women, breastfeeding women, or children. Due to the lack of safety data, it is advised that these groups avoid NAD+ injections.

 

*This list may not cover all possible side effects—consult a healthcare provider for concerns.

How should I use this medication?

For comprehensive guidance on how to use your medication, please refer to the detailed instructions provided on the white prescription label affixed to the medication box or prescription vial.

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It is to be administered subcutaneously. See detailed instructions here.

Where should I keep my medication?
Store refrigerated between 36°F to 46°F (2°C to 8°C). Keep out of reach of children and dispose of unused medicine after the expiration date—do not flush or pour down the drain.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.